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The CJC-1295/Ipamorelin cycle is a popular protocol among bodybuilders and athletes who seek to enhance natural growth hormone production, improve muscle mass retention, and accelerate recovery without the harsh side effects associated with higher doses of other growth hormone secretagogues. By combining the long-acting analogue CJC-1295 (also known as REMINYL) with the short-acting Ipamorelin peptide, users can achieve a sustained increase in endogenous growth hormone levels throughout the day and night, leading to more efficient protein synthesis, fat metabolism, and cellular repair.



Ipamorelin Cycle Guide: Optimal Dosage, Timing, and Best Peptide Stacks





CJC-1295 (Reminyl) – 100 µg per injection, administered once daily in the morning or evening depending on personal preference for sleep quality.


Ipamorelin – 50 µg per injection, typically given twice a day: first dose at 8 a.m. and second dose at 10 p.m. to mimic natural circadian peaks of growth hormone release.


Combined dosing can be adjusted in 25-µg increments if side effects such as mild water retention or tingling occur.


Cycle length – 6 to 8 weeks of continuous use, followed by a 2-week drug holiday to allow the body’s endocrine system to reset.


Best peptide stacks – Pairing CJC-1295/Ipamorelin with a low dose of a growth hormone releasing factor (GHRF) such as TB-500 or IGF-1 can further amplify anabolic effects, but should be approached cautiously due to increased risk of side reactions.



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When researching the CJC-1295/Ipamorelin cycle, look for peer-reviewed studies that measure serum growth hormone and insulin-like growth factor levels after repeated dosing. Reliable sources include scientific journals on endocrinology, pharmacology databases such as PubMed, and reputable peptide suppliers’ technical sheets that provide safety data and user testimonials.





Increased Natural Growth Hormone Production


• CJC-1295 stimulates the pituitary gland to release growth hormone over a prolonged period because it has a half-life of approximately 30 hours.

• Ipamorelin acts as a potent growth hormone releasing peptide, prompting short bursts of hormone secretion that complement the long-acting profile of CJC-1295.

• Together, they create a near-continuous elevation in growth hormone levels, which is associated with enhanced muscle protein synthesis, improved nitrogen balance, and accelerated recovery from intense training sessions.




The synergy between these two peptides also encourages the body to produce more natural growth hormone rather than relying solely on exogenous administration. This natural stimulation can reduce the likelihood of desensitization that sometimes occurs when high doses of single agents are used repeatedly.



In addition to anabolic benefits, users often report increased energy levels, better sleep quality, and a smoother recovery period between training blocks. By adhering to the dosage guidelines above and monitoring physiological responses, individuals can safely incorporate the CJC-1295/Ipamorelin cycle into their performance enhancement regimen while maintaining long-term endocrine health.

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